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Recurrence of hyperpigmentation in our patient was not observed at a one-year follow-up
activating-solution
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These strategies include ERAD E3 ubiquitin ligases that polyubiquitinate substrates by cooperating with E3 ubiquitin ligases that catalyze monoubiquitination or with E4 ligases that play a role in highly processive polyubiquitin chain elongation but not in the initial steps of ubiquitination, 144,145 often requiring sequential rounds of ubiquitination and deubiquitination
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