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The presence of oligopeptides from protein digestion in the stomach stimulates gastrin release, which enhances LES constriction (Reference Zeng, Ou and Wang81–Reference Soll and Walsh83)
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Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO
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