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Lynch syndrome associated tumours carry a high burden of insertion/deletion mutations due to the persistence of DNA replication errors in microsatellite rich areas of the genome, leading to the accumulation of a large number of frameshift mutations in the tumours of affected individuals
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6,7,20 There is an intimate connection between abnormal GST expression and multidrug resistance, unequivocally implicating GSTπ, a member of the GST family in tumor-drug resistance
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