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Increased levels of IgA and in some cases, IgM have been noted, and these have been directed against endotoxin components of gram negative bacteria and may be the cause of increased gut permeability noted in many people with ME/CFS
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In the presence of IL-4 and Il-13, the B cell undergoes class switching to produce IgE (43), which can induce the release of pro-inflammatory cytokines and the expression of HLA-DR
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