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For instance, resveratrol have demonstrated apoptotic and anti-proliferative effects on human cervical carcinoma by inducing cell shrinkage in HeLa cells and apoptosis through the activation of caspase-3 and -9, upregulation of the expression of the pro-apoptotic B-cell lymphoma (Bcl)-2-associated X protein and downregulation of the expression of the anti-apoptotic proteins Bcl-2 and Bcl-extra-large in HeLa cells, and increased expression of the p53, a protein that is essential for cell survival and cell cycle progression [54]
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