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Furthermore, various studies have demonstrated that MT -deficient mice are more vulnerable to oxidative stress-induced cellular and tissue damage as well as non-communicable diseases associated with oxidative stress [6, 114]
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417 When peroxide binds to the regulatory Fe II complex, metal-catalyzed oxidation triggers the incorporation of one atom of oxygen into one of the His in site 2 (either H36 of H91 in Bs PerR sequence, 443 labeled with a star in Figure 14D)
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