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The activation of the costimulatory receptor CD28 induces PDE4, resulting in the hydrolysis of cAMP, the induction of NF-κB, activator protein-1 (AP-1) and NFAT, as well as the activation and proliferation of T cells
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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Guha S., Alvarez S., Majumder K
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