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Being the first step in the metabolism and eventual removal of the drug from the body, GST is associated with chemotherapeutic resistance since exposure to these drugs is often associated with induction of GST, especially GST P1-1 (Dahllof et al., 1987
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A study in humans also concluded that the frequently observed postviral chronic fatigue and affective features after coronavirus disease (COVID) are related to high levels of inflammation, oxidative damage, and lowered antioxidant defenses [90]
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