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Mechanism of Action GHK-Cu exhibits a multifaceted mechanism, influencing gene expression, cellular signaling, and copper homeostasis: 2.1 Collagen and ECM Stimulation: • GHK-Cu upregulates genes for collagen (types I, III, IV, VII), elastin, and glycosaminoglycans (GAGs) by modulating transcription factors like SP1 and TGF-β
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During lineage specification and terminal differentiation, H3K9me3 is deposited and removed in a cell-type-specific fashion, suggesting an involvement in development (Hawkins et al., 2010
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