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It is estimated that 95–97% of thymocytes are eliminated due to not meeting these criteria ( Tn cells are activated by the binding of the T cell receptors (TCR) and the antigen peptides on the major histocompatibility complex (MHC) from antigen-presenting cells (APC) with the help of costimulatory molecules ( CD8 + Teff cells produce large amounts of perforin and granzyme B to eliminate foreign pathogens, viral-infected cells, and tumor cells ( + Teff cells secrete an array of cytokines and recruit other immune cells
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