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As a direct modulator of CSF volume and composition, the choroid plexus has been the subject of growing interest for its important roles in brain development and health
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At low doses (≈125 μg/kg), metformin activates AMPK, enhancing endothelial nitric oxide synthase (eNOS) activity, improving vascular function, and reducing myocardial injury (Gundewar et al., 2009)
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