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Many of the oxidative stress biomarker profiles are altered in ALS bio-samples and animal models, where it has been observed that oxidative stress promotes the aggregation of acetylated TDP-43 which hinders RNA binding and encourages the accumulation of insoluble, hyperphosphorylated TDP-43 species
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The crossover trial asked a narrower question: does 100 mg, in young healthy men, produce a detectable effect at 4, 8, or 12 hours
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