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In PD, due to pathological changes in the substantia nigra region of the brain, stimulated by factors such as oxidative stress and inflammatory responses, key proteins in the MAPK signaling pathway, such as extracellular signal-regulated kinase (ERK), may undergo abnormal activation or inhibition [143,144]
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Transplantation of these -differentiated cells has produced variable results and often gave rise to tissue overgrowth with formation of neuroepithelial tumors, probably linked to the presence of residual immature cells in the original grafts
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