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Itaconate suppresses aldolase A– a glycolytic enzyme that converts fructose 1,6-biphosphate into glyceraldehyde 3-phosphate – and shifts metabolism toward the PPP by interrupting glycolysis
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However, so far a role of IGF‐1 in development of SPCs following diagnosis of prostate cancer, breast cancer, colorectal cancer, or lung cancer has not been analyzed
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