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The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model | Theoretical Biology and Medical Modelling | Springer Nature Link
Cells were treated with the following inhibitors and metabolites: GSK864 (10μM), αKG (1mM), L-carnitine (1mM) and O-Acetyl-carnitine (1mM) for a period of 5 days, followed by inducing the DSBs with Tamoxifen (1μM) and shield-1 (1μM) for a period of 4 hours
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Like the GSH-based system, the TXN system is capable of directly scavenging ROS and can also make use of reversible oxidation of its key conserved cysteine residues (C-X-X-C) to reduce disulfide bridges in oxidized proteins
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