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25,32 Activated ASK1 and MLK3 then stimulate mitogen-activated protein kinase kinase kinase 4/7 (MKK4/7) and activate JNK to initiate a cascade effect
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Likewise, the flux of PUFAs into TAGs, concomitant with the biogenesis of lipid droplets from the ER, can be protective against ferroptosis in some cases by restricting the incorporation of PUFAs into phospholipids
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