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The protein has short (20 amino acids) luminal sections, followed by a 20 amino acid membrane-spanning helix (not shown in the above structure), followed by a large cytosolic domain, where it can interact with cytochrome P450, which is found in multiple places, including the ER, microsomal, and mitochondrial membranes, as well as the cytoplasm
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In this commentary we discuss the novel findings of Gerner et al
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