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Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)

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For the metabolomics study, we randomly selected 199 baseline IGRA-negative household contacts, including 71 IGRA converters (35%) and 128 (65% with repeatedly negative IGRA result (Fig