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Also in Ewing sarcoma, dusigitumab in combination with rapamycin or mTORC1/2 kinase inhibitor AZD2014 was more effective than single-agent dusigitumab in inhibiting in vivo tumor growth [74]
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Once activated, the RAS can contribute to insulin resistance, and increase blood pressure, oxidative stress and cell proliferation (193,197–201)
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