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Neurological insults, such as status epilepticus (SE), a condition involving prolonged, continuous seizures that are relatively uncommon among epilepsy patients [268], can be induced in experimental rodent models
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The rationale for targeting the IGF-1R is derived widely from cell culture experiments that demonstrate the importance of IGF-IR signaling in promoting proliferation, inhibiting apoptosis, and its involvement and impact on BC cells that are resistant to radiation and chemotherapy (Jones et al., 2009)
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