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(4) Autophagy intensity and CCI classification: ① Autophagy intensity: Detection of the expression of the autophagy-specific marker protein LC3B by immunohistochemistry
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4.2 Regulation of ferroptosis by inflammatory cytokines and immune signaling 4.2.1 Classic proinflammatory cytokines IL-1β can induce the synthesis of matrix-degrading enzymes MMP-13 and ADAMTS-5 by chondrocytes and synovial cells (117)
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