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Administration of carnosine to female 9-to-11-week-old C57BL/6 OlaHSD mice with EAE increased spinal cord carnosine levels and carnosine-acrolein quenching, suppressed inflammatory activity, caused a reduction in the acrolein adduct formation, and diminished the clinical severity of the disease [186]
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IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B
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