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Senescent macrophages, including bone marrow-derived macrophages exposed to high-dose radiation, also secrete IL-1Ξ±, IL-6, TNF-Ξ±, MCP-1, CCL2, CXCL10, CCL17, MMP2, MMP9, and MMP12 (Su L
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Among them, the RRM2 -KD-417 strain showed the highest knockdown efficiency and was therefore selected as a representative strain for subsequent experiments
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