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Targeting glutamine metabolism as a therapeutic strategy for cancer | Experimental & Molecular Medicine
Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]
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Brit Med J 2010;340:c2181
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