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В другом предпочтительном варианте выполнения настоящего изобретения, конъюгаты лекарство-линкер, в которых свободная тиольная группа соединена с линкерным фрагментом, вводят в реакцию с малеимид-функционализированным гидрогелем при температурах от комнатной до 4°С, более предпочтительно при комнатной температуре, в водном буферном растворе, имеющем значение рН 5.5-8, предпочтительно рН 6.5-7.5
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An exploratory, open-label, investigator-initiated study of interleukin-17 blockade in patients with moderate-to-severe papulopustular rosacea
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