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An association was also found between abnormal small intestinal permeability and a specific mutation in the NOD2 gene, which functions to modulate immune responses to intestinal bacteria, suggesting a genetic pathway in which an abnormal intestinal barrier could lead to chronic intestinal inflammation [85,86]
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The exact cause isn’t always clear, but contributing factors may include: Micro-trauma or injury to the penis Genetics Connective tissue disorders Certain medical conditions Regardless of the cause, Peyronie’s Disease can be distressing—but effective treatment options are available
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