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The post-synaptic density 95/Drosophila discs large/zona-occludens 1 (PDZ) binding domain in the claudin C-terminal domains interacts with intracellular TJ proteins such as ZO proteins, which in turn anchor the claudins to the actin cytoskeleton
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This substance was first isolated and described in the scientific literature in the 1990s by a team of Croatian scientists led by Professor Predrag Sikirič
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