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Cellular Activity Studies of 5a and Additional MD Simulations As with our original prodrug library, 5a and 5b were screened in cellulo in both PSMA-positive LNCaP cells and PSMA-negative PC3 cells, using antiproliferation assays and the direct measurement of BRD4 degradation by Western blotting
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The correlation of high ATX with shorter overall survival (OS) (p=0.005) and recurrence-free survival (RFS) (p 3 in 72.0% and 74.2%, 22.7% and 20.8%, and 5.3% and 5.0%, respectively)
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