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🧪 Glutathione Depletion Pathways 1. Precursor Depletion - Key bottleneck: Cysteine availability. - Source: Diet or hepatic transsulfuration (methionine → homocysteine → cysteine). - Failure mode: Downregulation of cystathionine γ‑lyase (CSE) during
[Abstract]2026 Feb 12:800:153270
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These complexities are further underscored by a recent report by Soriani et al., which suggests that CD38 can act as a decoy for extracellular cGAMP, a mediator of innate immunity
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