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Reactive oxygen and nitrogen species selectively modify pore-forming channel subunits: nitric oxide (•NO) S-nitrosylates critical cysteine thiols [83], peroxynitrite (ONOO − ) nitrates tyrosine residues [84], and hydrogen peroxide (H 2 O 2 ) oxidizes cysteine thiols to sulfenic (–SOH), sulfinic (–SO 2 H), and disulfide (–S–S–) forms [85], as illustrated in Figure 5 [86,87,88]
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