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DRP1 functions as a crucial regulator of mitochondrial fission, and its hyperactivation under pathological circumstances leads to excessive fragmentation of mitochondria, which in turn results in compromised mitochondrial function and increased levels of ROS
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The expression of TNF-α mRNA, monocyte chemoattractant protein 1 mRNA and toll-like receptors 3 and 4 was also increased in post-mortem brain
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