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For example, phosphorylation of Sp1 and CREB in response to increased intracellular cAMP enhances their binding to the NAGS promoter, while liver-specific transcription factors hepatocyte nuclear factor 1 and nuclear factor Y respond to glucagon and glucocorticoid signals by synergizing with enhancer elements to upregulate NAGS expression, adapting to changes in nitrogen excretion under fasting or stress (17,18)

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The reason for the discrepancy in these findings is unclear, but may relate to duration, pattern, or amount of alcohol consumption or the time of measurement in relation to the number of withdrawals or the time since withdrawal