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Preclinical studies (late 1990s to early 2000s): Animal studies conducted at Monash University demonstrated that chronic administration of AOD-9604 to obese mice produced significant reductions in body weight gain, increased in vivo fat oxidation, and elevated plasma glycerol levels (a marker of lipolysis)

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9 23 In a recent RCT in Bangalore, India, daily maternal vitamin B 12 supplementation (50 µg/day) during pregnancy through 6 weeks postpartum substantially improved maternal vitamin B 12 status and increased breast milk and infant plasma vitamin B 12 concentrations