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Ketamine promotes a cascade of cellular events that begin with the release of glu-tamate, the activation of AMPA receptors that activate mTOR-mediated plasticity, BDNF, and the synthesis of synaptic proteins that facilitate plasticity in structures such as the prefrontal cortex [137,138] or increase the activity of immature neurons without increasing neurogenesis [139]
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Patients with neurodegenerative disorders exhibit elevated levels of oxidative stress markers in their brain tissues [13]
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