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The incorporation of bone marrow mesenchymal stem cell (BM-MSC)-derived exosomes into hyaluronan-collagen hydrogels induces angiogenesis and neurogenesis through sequential processes: (1) endogenous neural stem cell (NSC) recruitment, (2) neuronal differentiation/vascularization, and (3) synergistic promotion of axonal regeneration, remyelination, synaptogenesis, and brain structural remodeling, ultimately restoring neurological function in TBI [215]
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Recent studies also indicate that excess intracellular iron can modulate necroptosis and pyroptosis, suggesting that disrupted iron homeostasis is not exclusive to ferroptosis
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