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OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body
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Notably, opioid binding to these peptides is significantly less than the adrenergic compounds, suggesting that the function of these extracellular regions of the opioid receptor has been optimized to facilitate allosteric control of the receptor by adrenergic compounds rather than to attract opioids to the receptor
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