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doi: 10.3389/fphar.2021.712876 222 YanFWangRLiSZhaoXJiangYLiuLet al
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As the unconventional XBP1 mRNA splicing by IRE1α and the subsequent activation of the spliced XBP1 protein expression are the major mechanism of ER homeostasis regulation by IRE1α 10 , we tested whether XBP1 plays a role in IRE1α-mediated ferroptosis sensitization
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