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Medication is often the right starting point for someone who is: ‍ Early in treatment for depression Managing mild to moderate symptoms Looking to avoid in-clinic visits Someone who has responded well to an antidepressant before ‍ TMS is generally considered for someone who: ‍ Has tried multiple antidepressants without adequate relief Cannot tolerate medication side effects Prefers a non-drug approach Has treatment-resistant depression ‍ Many people use both at different points, and some use them together

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In conditions where cellular ATP levels are low, AMP or ADP can displace ATP from the regulatory γ-subunit and this initiates AMPK activation through an allosteric mechanism