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Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders
While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohol’s ability to assume cysteine’s function in stabilizing deprotonated GS − , the only other Pt GSTF8 variants to keep an—albeit reduced—flavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig
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