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CLOCK−/− and BMAL1−/− mice exhibit disorders of glucose metabolism and circadian changes in circulating glucose and triglycerides, which lead to obesity, hyperlipidemia, and diabetes ( BMAL1 , PER2 , and CRY1 in visceral fat is closely related to the increase in waist circumference which is an indicator of metabolic syndrome ( The second is that the circadian clock system may control the rate-limiting steps of the metabolic process ( + biosynthesis ( + is involved in the process of aging and lipid metabolism ( + regulates the circadian clock system through SIRT1
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