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igf-1 lr3 anti aging Late-life targeting of the receptor improves healthspan and lifespan in female mice SkinBrightening
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CYP2J2 over-expression also attenuated increased PDK4 expression, which has been suggested to contribute to DCM by decreasing the pyruvate dehydrogenase complex
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(3) Cholesterol Metabolism Disruption: ApoE4 increases cholesterol secretion from astrocytes, which enhances lipid raft formation in neurons, aiding APP localization and processing [16]
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