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Similarly, expression of the nuclear form (initially called sperm-nuclei specific form, nGPX4) with a long N-terminal extension including a nuclear localization signal and DNA binding domains resembling those present in protamines, is constrained to testis, specifically in late spermatids [77]
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This pathway is accountable for the enzymatic transformation of intracellular glucose to sorbitol with the help of AR, after which the resulting sorbitol is further oxidized to fructose by SDH (Fig
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