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Current research indicates these peptides may help regulate several important mechanisms, including: • Brain-derived neurotrophic factor (BDNF), which is linked to learning, memory, and neuron health • Dopamine and serotonin activity, which play central roles in mood, focus, and emotional balance • Neuroinflammatory pathways that may influence brain function under stress • Cortical neuroplasticity and synaptic remodeling, both essential for adaptation and cognitive flexibility In preclinical research, Semax has been associated with neuroprotective effects in ischemic models, suggesting potential support for brain resilience under injury-related conditions

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However, it is difficult to determine whether the level of training is relevant, as the other two studies included in the review involving trained athletes showed no effect on cognitive function [14, 15]