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Glossary Abbreviations ACh acetylcholine m/n AChR muscarinic/nicotinic ACh receptor 2-APB 2-aminoethyl diphenylborinate BBB blood–brain barrier AD Alzheimer’s disease BDNF brain-derived neurotrophic factor CaMKII Ca 2+ /calmodulin-dependent kinase II CREB cAMP response element-binding protein EGT l-ergothioneine E-MEM Eagle’s minimal essential medium ER endoplasmic reticulum ERY l-hercynine FBS fetal bovine serum IP 3 R inositol 1,4,5-triphosphate receptor MAPK mitogen-activated protein kinase MCI mild cognitive impairment mer-His 2-mercapto-l-histidine NDD neurodegenerative disease NGF nerve growth factor NT neurotrophin OCTN1 organic cation transporter 1 PBS phosphate-buffered saline PD Parkinson’s disease PHT1 peptide/histidine transporter 1 PKA protein kinase A PLL poly l-lysine solution RA retinoic acid RIPA radioimmunoprecipitation assay RyR ryanodine receptor RFU relative fluorescence unit TrkB tyrosine receptor kinase B Data Availability Statement All data generated or analyzed during this study are included in this article and supplementary documents