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Furthermore, certain chemicals, including those occurring naturally in fruits and cruciferous vegetables can act as inducers of GST genes through a range of responsive elements and such inductions are part of GSTs adaptive response mechanisms to chemical insult caused by electrophiles [7]

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Upon recognition, macrophages undergo proinflammatory polarization and phagocytose of oxidized low density lipoprotein (oxLDL), ultimately leading to proatherogenic cytokine production and the formation of foam cells that contribute to plaque progression 2 (Fig