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The ULK1 complex consists of three regulatory subunits Atg13, the focal adhesion kinase family interacting protein of 200KDa (FIP200), Atg101 and the core Ser/Thr kinase ULK1

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In CD, the early and effective use of TNF-α inhibitors has also been shown to prevent the development of disease complications, for example, strictures or penetrating ulcerations and disease progression, which led to a lower risk of surgery during disease progression and significantly reduced the risk of penetrating complications, but not stenosing complications [60]