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The combination of choline kinase-α inhibitor MN58b and AMPK agonist metformin could reduce synovial vascular opacification area by 43% through dual inhibition of phosphatidylcholine synthesis and glycolytic enzyme expression ( Current research has explored the combined application of HK2 inhibitors (e.g., 2-DG) and AMPK agonists (e.g., Metformin) in RA models, demonstrating synergistic inhibitory effects on synovitis and bone erosion