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Reaction assay of GPX activity contained 1 mM ethylenediaminetetraacetic acid, 200 mM NADPH, 1 mM NADPH-dependent thioredoxin reductase, 2 mM TRX, and 250 mM H 2 O 2
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Phosphorylation of IRS-1 by p70S6K results in reduced insulin-mediated signaling via the insulin receptor, thereby, increasing the metabolic burden on pancreatic β-cells
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