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Supplementary material The Supplementary Material for this article can be found online at: Glossary Akt Protein Kinase B Bax BCL2-Associated X protein Bcl-2 B-cell lymphoma/leukemia-2 DISC Death-inducing signaling complex EMs Endometriosis ER Endoplasmic reticulum ERK Extracellular signal-regulated kinase FADD Fas-associated death domain GPX4 Glutathione Peroxidase 4 GSDMD Gasdermin D GSH Glutathione HO-1 Heme Oxygenase-1 IhOESCs Immortalized human ovarian endometriotic stromal cell lines IL-6 Interleukin 6 IL-1β Interleukin-1β LC3 Light Chain 3 MAPK Mitogen-activated protein kinase MDA Malondialdehyde MLKL Mixed lineage kinase domain-like protein MMP Matrix metalloproteinase mTOR mammalian target of rapamycin NF-κB Nuclear Factor kappa-B NLRP3 NLR family pyrin domain-containing protein 3 Nrf2 Nuclear factor erythroid 2-related factor 2 PCD Programmed cell death PI3K Phosphatidylinositol 3-kinase RIPK Receptor-interacting protein kinase ROS Reactive oxygen species SOD Superoxide dismutase TGF-β Transforming Growth Factor Beta Receptor TNF-α Tumor necrosis factor-α HIF-1α Hypoxia-Inducible Factor -1α References 1 AnM.FuX.MengX.LiuH.MaY.LiY.et al (2024)

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Boosting EAAT1/2 restores synaptic glutamate clearance and dampens downstream cytokines39