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AG-946 differs pharmacokinetically and pharmacodynamically from first-generation mitapivat in that AG-946 has greater potency, a longer half-life (∼80-110 hours vs 3-6 hours), and more prolonged effects on 2,3-DPG and ATP levels (observed at least 14 days after last dose in healthy controls), 37 which provides a potential self-tapering effect
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